March 12, 2001Archives of Internal Medicine
The Role of Angiotensin Receptor Blockers in the Management of Chronic Heart Failure
Why the study?
Do angiotensin II receptor blockers (ARBs) provide an effective alternative to ACE inhibitors in the management of chronic heart failure?
Population
Patients with chronic heart failure, particularly those who are ACE inhibitor-intolerant
Comparison
Angiotensin II receptor blockers (ARBs) vs Angiotensin-converting enzyme (ACE) inhibitors
Design
Review
Authors
Discussion
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Member takes
Implication
Supports restricting ARBs to ACEI-intolerant HF patients; leaves open need for direct randomized comparisons.
Structured PICO
Do angiotensin II receptor blockers (ARBs) provide an effective alternative to ACE inhibitors in the management of chronic heart failure?
P
Population
Patients with chronic heart failure, particularly those who are ACE inhibitor-intolerant
I
Intervention
Angiotensin II receptor blockers (ARBs)
C
Comparator
Angiotensin-converting enzyme (ACE) inhibitors
ARBs are currently recommended primarily as an alternative therapy for chronic heart failure patients who are intolerant to ACE inhibitors.
Cite This Study
Jamali et al. (2001) studied this question.