Why the study?
Does PET with 11C-CGP-12177 accurately and safely assess left ventricular beta-adrenergic receptor concentration in patients with idiopathic dilated cardiomyopathy compared to normal controls?
Population
18 subjects total: 10 patients with heart failure related to idiopathic dilated cardiomyopathy and 8 normal…
Comparison
Positron emission tomography with intravenous… vs Normal subjects (healthy controls)
Design
Case-control
Authors
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May enable noninvasive PET monitoring of beta-receptor density in dilated cardiomyopathy; leaves open clinical utility pending prospective validation.
Does PET with 11C-CGP-12177 accurately and safely assess left ventricular beta-adrenergic receptor concentration in patients with idiopathic dilated cardiomyopathy compared to normal controls?
PET with 11C-CGP-12177 provides a safe and reliable noninvasive method to quantify the reduction of left ventricular beta-adrenergic receptors in patients with idiopathic dilated cardiomyopathy.
Merlet et al. (1993) studied this question.
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