Key result
A novel double-inversion fast spin-echo MRI method successfully generated co-registered lipid and water images with reduced flow artifacts and excellent contrast in ex vivo and in vivo models.
This novel double-inversion fast spin-echo MRI method may improve the detection of myocardial lipid infiltration, which is relevant for diagnosing conditions like arrhythmogenic right ventricular dysplasia.
May aid myocardial lipid detection in ARVD; leaves open prospective clinical validation before adoption.
In this work we present a new method for the improved detection of lipid infiltration in the heart. The method employs a double-inversion fast spin-echo technique where the acquisition of water- and lipid-suppressed k-space data is alternated between TR periods to produce co-registered lipid and water images from data acquired in a breath hold. The lipid and water images can then be combined to generate a lipid/water image with reduced artifacts due to flow and excellent contrast between lipid and myocardium. The method is demonstrated in ex vivo tissue and in vivo. This novel method may improve the detection of lipid infiltration in the heart in pathologies such as arrhythmogenic right ventricular dysplasia.
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Altbach et al. (2005) studied Lipid infiltration in the heart (e.g., arrhythmogenic right ventricular dysplasia). Double-inversion fast spin-echo MRI method with interleaved acquisition was evaluated on Generation of co-registered lipid and water images with reduced flow artifacts and excellent contrast. A novel double-inversion fast spin-echo MRI method successfully generated co-registered lipid and water images with reduced flow artifacts and excellent contrast in ex vivo and in vivo models.
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