Myocardial Fat Imaging
Key result
Multi-echo fat-water separated MRI provides a sensitive means of detecting intramyocardial fat with positive contrast and resolves artifacts associated with conventional chemical-shift fat suppression.
Why the study?
Does fat-water-separated MRI improve the detection of intramyocardial fat compared to conventional chemical-shift fat suppression?
Structured PICO
Does fat-water-separated MRI improve the detection of intramyocardial fat compared to conventional chemical-shift fat suppression?
P
Population
Patients with ischemic and nonischemic cardiomyopathies (examples presented in a review context)
I
Intervention
Fat-water-separated imaging in the heart by MRI (multi-echo methods)
C
Comparator
Conventional chemical-shift fat suppression
O
Outcome
Detection of intramyocardial fat and characterization of fibrofatty infiltrationsurrogate
Fat-water-separated MRI is a sensitive and advantageous technique for detecting intramyocardial fat and characterizing fibrofatty infiltration in cardiomyopathies.
Limitations
- T1-weighted contrast, if uncorrected, may lead to overestimation of fat
- Partial volume effects at the border between epicardial fat and myocardium require high spatial resolution
Authors
Discussion
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Implication
Fat-water MRI may aid intramyocardial fat detection in cardiomyopathies; leaves open prospective validation before clinical adoption.
Cite This Study
Kellman et al. (2010) conducted a review in Cardiomyopathies. Fat-water separated MRI vs. Conventional chemical-shift fat suppression was evaluated. Multi-echo fat-water separated MRI provides a sensitive means of detecting intramyocardial fat with positive contrast and resolves artifacts associated with conventional chemical-shift fat suppression.