Peptides interfering with adhesive protein binding to GP IIb-IIIa inhibit platelet adherence to vascular subendothelium only at high wall shear rates, suggesting different recognition specificities for high shear adherence versus fluid-phase binding or static adhesion.
No takes yet. Share an insight, caveat, or question.
May selectively reduce high-shear platelet adhesion; leaves open distinct GP IIb-IIIa specificities versus static or low-shear conditions.
Lawrence et al. (1990) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: