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November 1, 1999Cardiovascular ResearchOpen Access

Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocyte contractile dysfunction in heart failure

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Authors

SKShintaro KinugawaHeart Failure & Transplant

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Implication

Myocyte Ca2+ or myofilament defects in canine HF highlight cellular targets; leaves open translation to human therapies.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Shintaro Kinugawa (1999) studied this question.

synapsesocial.com/papers/6a8b99260c58d86fb4cacaf5 https://doi.org/10.1016/s0008-6363(99)00205-9

Topics

Heart failure HFrEF treatment

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Role of SR Ca2+-ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure1998 · 25 citations
2Calcium Sensitivity of Isometric Tension Is Increased in Canine Experimental Heart Failure1995 · 89 citations
3Relation between steady-state force and intracellular [Ca2+] in intact human myocardium. Index of myofibrillar responsiveness to Ca2+.1990 · 100 citations
4Abnormal myocyte Ca<sup>2+</sup>homeostasis in rabbits with pacing-induced heart failure1998 · 87 citations
5Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure1996 · 576 citations