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January 7, 2009Journal of Cerebral Blood Flow & MetabolismOpen Access

Angiotensin II Modulates BBB Permeability via Activation of the AT 1 Receptor in Brain Endothelial Cells

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Population

Blood-brain barrier microvessel endothelial cells (MECs)

Comparison

Angiotensin II for 0 to 6 hours, with or without… vs Control or Angiotensin II alone

Design

Preclinical

Follow-up

6 hours

Authors

MFMelissa A. Fleegal-DeMottaSDShinya DoghuWBWilliam A. Banks

Discussion

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Overview

AT1 blockade may limit BBB permeability in hypertensive models; leaves open translation to human encephalopathy prevention.

Structured PICO

P
Population
Blood-brain barrier microvessel endothelial cells (MECs)
I
Intervention
Angiotensin II (100 nmol/L) for 0 to 6 hours, with or without pretreatment with telmisartan (1 micromol/L) or PD123,319 (1 micromol/L)
C
Comparator
Control (no Angiotensin II) or Angiotensin II alone
O
Outcome
Permeability to (125)I-albumin and transendothelial electrical resistance (TEER)surrogate

Angiotensin II directly increases blood-brain barrier permeability via AT1 receptor activation, providing a potential mechanistic explanation for hypertensive encephalopathy.

Cite This Study

Fleegal-DeMotta et al. (2009) studied this question.

synapsesocial.com/papers/6a8b99e6bc51310b2bdec634https://doi.org/10.1038/jcbfm.2008.158
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Also Consider

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  1. 1Effects of the AT1 receptor antagonist on adhesion molecule expression in leukocytes and brain microvessels of stroke-prone spontaneously hypertensive rats2000 · 39 citations
  2. 2Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature2007 · 60 citations
  3. 3AT 1 Receptor Blockade Regulates the Local Angiotensin II System in Cerebral Microvessels From Spontaneously Hypertensive Rats2006 · 98 citations
  4. 4Angiotensin At1Receptor Signalling Pathways In Neurons2002 · 95 citations
  5. 5CRITICAL CARE ISSUES FOR THE NEPHROLOGIST: Current Diagnosis and Management of Hypertensive Emergency2006 · 44 citations