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November 16, 2011Experimental & Translational Stroke MedicineOpen Access

Role of blood cell-associated angiotensin II type 1 receptors in the cerebral microvascular response to ischemic stroke during angiotensin-induced hypertension

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Population

Wild type, AT1aR-/-, and bone marrow chimera mice with either a BC+/EC+ or BC-/EC+ distribution of AT1aR

Comparison

Angiotensin II-induced hypertension followed by… vs Normotensive mice and WT mice

Design

Preclinical

Authors

MNMutsumi NagaiSTSatoshi TeraoSVShantel Vital

Discussion

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Overview

Distinct AT1aR roles on blood versus endothelial cells extend mechanistic insight into hypertensive stroke; leaves open selective targeting in humans.

Structured PICO

P
Population
Wild type (WT), AT1aR-/-, and bone marrow chimera mice with either a BC+/EC+ (WT→WT) or BC-/EC+ (AT1aR-/-→WT) distribution of AT1aR
I
Intervention
Angiotensin II-induced hypertension followed by ischemia and reperfusion (I/R)
C
Comparator
Normotensive mice and WT mice
O
Outcome
Adhesion of leukocytes and platelets in venules, blood brain barrier (BBB) permeability, and infarct volumesurrogate

Both blood cell- and endothelial cell-associated AT1aR contribute to brain injury responses to ischemic stroke during Ang II-hypertension, with distinct roles in inflammation and tissue necrosis.

Cite This Study

Nagai et al. (2011) studied this question.

synapsesocial.com/papers/6a9540933b139fbb56b2be0fhttps://doi.org/10.1186/2040-7378-3-15
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