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August 31, 2010MicrocirculationOpen Access

Mechanisms Underlying the Cerebral Microvascular Responses to Angiotensin II-Induced Hypertension

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Population

Wild type (WT) and mutant mice (Rag-1(-/-), RANTES(-/-), P-selectin(-/-), and bone marrow chimeras)

Comparison

Chronic Angiotensin II administration via… vs Wild type vs mutant mice

Design

Preclinical

Follow-up

two weeks

Authors

SVShantel VitalSTSatoshi TeraoMNMutsumi Nagai

Discussion

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Overview

No immediate clinical implications for hypertension; leaves open vessel wall AT1r targeting for cerebral microvascular protection in translational studies.

Structured PICO

P
Population
Wild type (WT) and mutant mice (Rag-1(-/-), RANTES(-/-), P-selectin(-/-), and bone marrow chimeras)
I
Intervention
Chronic Angiotensin II (AngII) administration via implanted osmotic pumps for two weeks
C
Comparator
Wild type vs mutant mice
O
Outcome
Blood-brain barrier (BBB) permeability and blood cell (leukocyte and platelet) adhesion in the cerebral microvasculaturesurrogate

AT1 receptors on the vessel wall mediate AngII-induced cerebral microvascular dysfunction, with distinct pathways governing blood cell recruitment versus blood-brain barrier failure.

Cite This Study

Vital et al. (2010) studied this question.

synapsesocial.com/papers/6a8647c0da4bf993812ed100https://doi.org/10.1111/j.1549-8719.2010.00060.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Modulates BBB Permeability via Activation of the AT 1 Receptor in Brain Endothelial Cells2009 · 183 citations
  2. 2Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature2007 · 60 citations
  3. 3Role of Blood Cell–Associated AT1 Receptors in the Microvascular Responses to Hypercholesterolemia2005 · 37 citations
  4. 4Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.1997 · 253 citations
  5. 5Angiotensin II AT <sub>1</sub> Blockade Normalizes Cerebrovascular Autoregulation and Reduces Cerebral Ischemia in Spontaneously Hypertensive Rats2000 · 264 citations