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October 26, 2010HypertensionOpen Access

Angiotensin II–Mediated Microvascular Thrombosis

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Population

Wild-type and AT1 receptor-deficient mice; isolated murine platelets

Design

Preclinical

Follow-up

2 weeks

Authors

ESElena Y. SenchenkovaInstitute of Evolutionary Physiology and BiochemistryJRJanice RussellLouisiana State UniversityLALidiana D. Almeida-PaulaLouisiana State University Health Sciences Center Shreveport

Discussion

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Implication

Hypothesis-generating for non-AT1 pathways in hypertension-associated thrombosis; human studies required before any clinical inference.

Structured PICO

P
Population
Wild-type and AT1 receptor-deficient mice; isolated murine platelets
I
Intervention
Angiotensin II administration via ALZET pump for 2 weeks, with or without pharmacological antagonism of AT1, AT2, AT4, endothelin 1, and bradykinin 1 and 2 receptors
O
Outcome
Thrombus development in mouse cremaster microvessels quantified by time of onset of the thrombus and time to blood flow cessation after light/dye injurysurrogate

Angiotensin II-induced hypertension enhances microvascular thrombosis through a mechanism involving AT2, AT4, bradykinin 1, and endothelin 1 receptors, independent of AT1 receptors.

Cite This Study

Senchenkova et al. (2010) studied this question.

synapsesocial.com/papers/6a82c4f7d38da709b0133c4chttps://doi.org/10.1161/hypertensionaha.110.158220

Topics

Hypertension management
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