Why the study?
Does tolamolol reduce blood pressure variability in untreated patients?
Does tolamolol reduce blood pressure variability in untreated patients?
Tolamolol effectively lowers mean blood pressure and heart rate but does not alter 24-hour blood pressure variability.
Tolamolol was associated with lower mean BP and HR but unchanged variability; leaves open whether beta-blockers modulate BP variability.
The direct arterial blood pressure was monitored over 24 hours in unrestricted untreated patients in order to obtain the average pressure and standard deviation over 24 hours. The standard deviation was taken as the index of variability of pressure. In eight subjects the study was repeated three months after commencement of treatment with a beta-adrenergic blocking agent (tolamolol, 300 mg/day). In these subjects tolamolol resulted in a fall in mean blood pressure from 107 to 92 mmHg (P less than 0-05) and a fall in heart rate from 82 to 70 beats per minute (P less than 0-01). The variability in blood pressure, however, was unaffected by treatment.
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West et al. (1976) studied this question.
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