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June 1, 1997European Journal of Endocrinology

Role of the renin-angiotensin system in the development of thyroxine-induced hypertension

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Why the study?

Does captopril prevent hypertension in rats with thyroxine-induced hyperthyroidism?

Population

Rats with thyroxine (T4)-induced hypertension and hyperthyroidism

Comparison

Captopril in drinking water for 6 weeks vs T4 alone and control rats (tap water)

Design

Preclinical

Follow-up

6 weeks

Authors

CRCipriano Garcia del RioUniversité d'AngersMMMaría Rosario R MorenoAOAntonio OsunaUniversidad de Granada

Discussion

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Implication

Hypothesis-generating for RAS blockade in thyrotoxic hypertension models; does not inform human practice.

Structured PICO

Does captopril prevent hypertension in rats with thyroxine-induced hyperthyroidism?

P
Population
Rats with thyroxine (T4)-induced hypertension and hyperthyroidism
I
Intervention
Captopril in drinking water (1.38 mmol/l) for 6 weeks
C
Comparator
T4 alone and control rats (tap water)
O
Outcome
Mean arterial pressure (MAP) measured by intra-arterial determination in conscious ratssurrogate

Chronic blockade of the renin-angiotensin system with captopril prevents thyroxine-induced hypertension and improves renal function in hyperthyroid rats, though it does not reverse cardiac hypertrophy.

Cite This Study

Rio et al. (1997) studied this question.

synapsesocial.com/papers/6a8ba91a0ca85c7e33deffachttps://doi.org/10.1530/eje.0.1360656

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Involvement of renin-angiotensin system in the reduced pressure natriuresis response of hyperthyroid rats1995 · 20 citations
  2. 2Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling2003 · 125 citations
  3. 3Losartan is more effective than angiotensin (1–7) in preventing thyroxine-induced renal injury in the rat2024
  4. 4Effects of chronic administration of captopril on blood pressure and the renin-angiotensin-aldosterone system in normotensive rats.1983 · 9 citations
  5. 5An Experimental Study on the Effects of the Chronic Administration of an Angiotensin Converting Enzyme Inhibitor (Captopril) on Blood Pressure and the Renin-Angiotensin-Aldosterone System1980