Why the study?
Does labetalol improve blood pressure reduction compared to acebutolol alone or with dihydralazine in patients with moderate essential hypertension?
Does labetalol improve blood pressure reduction compared to acebutolol alone or with dihydralazine in patients with moderate essential hypertension?
Labetalol is an effective antihypertensive agent with comparable or slightly superior potency to acebutolol-based regimens in moderate essential hypertension.
May warrant labetalol consideration in moderate hypertension; leaves open confirmation versus acebutolol regimens in randomized trials.
1 Labetalol, an alpha- and beta- adrenoceptor blocking drug, was compared with acebutolol, alone or associated with dihydralazine in forty patients with moderate essential hypertension. 2 Labetalol (400--800 mg daily) seemed to have a slightly higher potency than acebutolol alone (400--800 mg daily). 3 Labetalol (1200--1600 mg daily) had the same potency as the combination of acebutolol (400--800 mg daily) and dihydralazine (50--100 mg daily). 4 Contrarily to acebutolol, the drop in blood pressure with labetalol was not correlated with initial plasma renin activity. 5 Labetalol side effects were minor and did not lead to drug withdrawal.
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Thibonnier et al. (1980) studied this question.
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