Key result
Labetalol (300 mg twice daily) was as effective as propranolol (80 mg twice daily) and more effective than hydrallazine (50 mg twice daily) alone for treating moderate hypertension.
Why the study?
Does labetalol improve blood pressure control compared to placebo, propranolol, hydralazine, or hydralazine plus propranolol in patients with moderate hypertension?
Population
Patients with moderate hypertension
Comparison
Labetalol (300 mg twice a day) vs Placebo, propranolol alone, hydralazine alone…
Design
RCT, randomized crossover, double-blind
Authors
Loading...
Labetalol matches propranolol or combination efficacy; leaves open its role versus modern agents in larger outcome trials.
RCT
Double-blind
Crossover
Does labetalol improve blood pressure control compared to placebo, propranolol, hydralazine, or hydralazine plus propranolol in patients with moderate hypertension?
Labetalol is an effective monotherapy for moderate hypertension, offering comparable efficacy to propranolol and superior efficacy to hydralazine alone.
West et al. (1980) conducted an RCT in Moderate hypertension. Labetalol vs. Placebo, propranolol, hydrallazine, and hydrallazine plus propranolol was evaluated on Efficacy. Labetalol (300 mg twice daily) was as effective as propranolol (80 mg twice daily) and more effective than hydrallazine (50 mg twice daily) alone for treating moderate hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: