February 1, 1989Cardiovascular Research

Forskolin potentiates myocardial reactive hyperaemia in the open chest dog: the contribution of adenylate cyclase

View Full Paper

Ask AI

Bookmark

Population

17 open chest dogs (10 in the first experiment, 7 in the second experiment)

Comparison

Intracoronary forskolin infusions alone or… vs Baseline conditions prior to infusion, or…

Design

Preclinical

Authors

KHKazuyoshi HinaHeart Rhythm Society HWHideomi WatanabeGunma University MUM UeedaOkayama University

Discussion

Member takes

Implication

Hypothesis-generating for adenylate cyclase in coronary reactive hyperemia; human studies needed before clinical relevance.

Structured PICO

Population

17 open chest dogs (10 in the first experiment, 7 in the second experiment)

Intervention

Intracoronary forskolin infusions (producing plasma concentrations between 0.16 and 0.34 mumol.litre-1) alone or simultaneously with 10 mumol of 8-phenyltheophylline

Comparator

Baseline conditions prior to infusion, or forskolin infusion without 8-phenyltheophylline

Outcome

Repayments of flow debt (myocardial reactive hyperaemia) following brief coronary occlusions of 15 s, 20 s, and 30 ssurrogate

Forskolin potentiates myocardial reactive hyperaemia in an open chest dog model, demonstrating that adenylate cyclase and adenosine play a significant role in the metabolic regulation of reactive hyperaemia.

Cite This Study

Hina et al. (1989) studied this question.

synapsesocial.com/papers/6a8bb18ef71b672e3df48e63 https://doi.org/10.1093/cvr/23.2.104

View Full Paper

Ask AI

Bookmark

Forskolin potentiates myocardial reactive hyperaemia in the open chest dog: the contribution of adenylate cyclase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Forskolin potentiates myocardial reactive hyperaemia in the open chest dog: the contribution of adenylate cyclase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider