Why the study?
The authors investigated the potential of a transmission line model as a digital twin of aneurysmal aorta to enable personalized monitoring.
Can a transmission line model applied to tonometry waveforms serve as a digital twin to detect physiological changes in abdominal aortic aneurysm patients?
Can a transmission line model applied to tonometry waveforms serve as a digital twin to detect physiological changes in abdominal aortic aneurysm patients?
A transmission line model using tonometry waveforms can detect physiologically explainable changes in arterial compliance and inertance, showing potential as a digital twin for personalized AAA monitoring.
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May support noninvasive AAA monitoring; leaves open prospective validation of tube-load models for clinical use.
We investigated the potential of the transmission line model as a digital twin of aneurysmal aorta by comparatively analyzing how a uniform lossless tube-load model were fitted to the carotid and femoral artery tonometry waveforms pertaining to (i) 79 abdominal aortic aneurysm (AAA) patients vs their matched controls (CON) and (ii) 35 AAA patients before vs after endovascular aneurysm repair (EVAR). The uniform lossless tube-load model fitted the tonometry waveforms pertaining to AAA as well as CON and EVAR. In addition, the parameters in the tube-load model exhibited physiologically explainable changes: when normalized, both pulse transit time and reflection coefficient increased with AAA and decreased after EVAR, which can be explained by the increase in arterial compliance and the decrease in arterial inertance due to the aortic expansion associated with AAA. In sum, the tube-load model may have the potential as a digital twin to enable personalized AAA monitoring.
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KIM et al. (2024) studied this question.
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