Why the study?
Does prophylaxis reduce overall mortality and fatal pulmonary embolism in patients undergoing major orthopedic surgery?
Population
Patients undergoing major orthopedic surgery (elective hip and knee replacement, hip fracture surgery)
Comparison
Prophylaxis (7 to 14 days) vs Without prophylaxis
Design
Meta-analysis
Authors
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Even with prophylaxis, vascular events cause half of post-hip fracture deaths; leaves open whether intensified regimens can further reduce mortality.
Does prophylaxis reduce overall mortality and fatal pulmonary embolism in patients undergoing major orthopedic surgery?
Prophylaxis reduces overall mortality and fatal pulmonary embolism following major orthopedic surgery, though vascular events remain a leading cause of death.
Caprini et al. (2005) studied this question.
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