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August 1, 1988The Journal of Infectious Diseases

Prophylactically Administered Retrovir(R) in Health Care Workers Potentially Exposed to the Human Immunodeficiency Virus

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Authors

SLStephen W. LaFonNational Institutes of HealthSLSandra Nusinoff LehrmanNational University of SingaporeDBDavid W. BarryNational Institutes of Health

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Implication

Clinical evaluation reveals outcomes of prophylactic zidovudine in health care workers exposed to HIV, highlighting strategies for occupational post-exposure prevention.

Key Points

  • To evaluate the safety, tolerance, and prophylactic utility of Retrovir (zidovudine) administration in health care workers following potential occupational exposure to HIV.
  • Administered prophylactic Retrovir (zidovudine) to health care personnel following documented or suspected occupational exposure to HIV-contaminated fluids.
  • Monitored treated personnel for clinical tolerance, adverse reactions, and evidence of subsequent HIV seroconversion.
  • Specific numerical event rates, effect sizes, and confidence intervals are not provided in the source abstract.
  • Evaluated the practical feasibility and safety profile of zidovudine regimens when used as immediate post-exposure prophylaxis in healthcare settings.

Cite This Study

LaFon et al. (1988) studied this question.

synapsesocial.com/papers/6a8bb399de5ec4e001e3cf61https://doi.org/10.1093/infdis/158.2.503
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Workplace Safety Considerations in Post-Exposure HIV Prophylaxis: A Case Report of Atypical Hypersensitivity in a Healthcare Worker2026
  2. 22025 US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Post-exposure Prophylaxis in Healthcare Settings2025 · 5 citations
  3. 3Preexposure prophylaxis for preventing HIV infection: Routine practice in primary care2024
  4. 4How Would You Manage HIV Pre-exposure Prophylaxis in This Patient With Medical Comorbidities?2024 · 2 citations
  5. 5Drug Exposure of Long-Acting Cabotegravir and Rilpivirine in Older People With Human Immunodeficiency Virus: A Pharmacokinetic Modeling Study2024 · 11 citations