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July 1, 1967CirculationOpen Access

The Electrophysiological Properties of Diphenylhydantoin Sodium as Compared to Procaine Amide in the Normal and Digitalis-Intoxicated Heart

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Why the study?

Does diphenylhydantoin sodium improve electrophysiological properties compared to procaine amide in the normal and digitalis-intoxicated heart?

Population

Normal and digitalis-intoxicated hearts

Comparison

Diphenylhydantoin sodium vs Procaine amide

Design

Preclinical

Authors

RHRichard H. HelfantElectrophysiologyBSBenjamin J. ScherlagElectrophysiologyADAnthony N. DamatoMontefiore Medical Center

Discussion

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Implication

May warrant human trials in digitalis toxicity; leaves open clinical translation from this animal model.

Structured PICO

Does diphenylhydantoin sodium improve electrophysiological properties compared to procaine amide in the normal and digitalis-intoxicated heart?

P
Population
Normal and digitalis-intoxicated hearts
I
Intervention
Diphenylhydantoin sodium
C
Comparator
Procaine amide
O
Outcome
Electrophysiological properties including ventricular automaticity, intraventricular conduction, atrioventricular (A-V) conduction, and sinus ratesurrogate

Diphenylhydantoin sodium demonstrates superior electrophysiological properties compared to procaine amide for the treatment of digitalis-induced arrhythmias by antagonizing digitalis action on the A-V node without worsening intraventricular conduction.

Cite This Study

Helfant et al. (1967) studied this question.

synapsesocial.com/papers/6a8bb41877493d51bfdee62fhttps://doi.org/10.1161/01.cir.36.1.108
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diphenylhydantoin Sodium in Cardiac Arrhythmias1965 · 133 citations
  2. 2The Effect of Diphenylhydantoin Sodium (Dilantin), Procaine Hydrochloride, Procaine Amide Hydrochloride, and Quinidine Hydrochloride upon Ouabain-Induced Ventricular Tachycardia in Unanesthetized Dogs1954 · 75 citations
  3. 3The Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular Tachycardia1958 · 63 citations
  4. 4Sodium Diphenylhydantoin in the Treatment of Recurrent Cardiac Arrhythmias1965 · 58 citations