Why the study?
Does diphenylhydantoin sodium suppress arrhythmias at specific plasma levels in patients with ventricular or atrial arrhythmias?
Population
Patients with a variety of arrhythmias, including ventricular arrhythmias in various clinical conditions and…
Design
Cohort
Authors
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May support plasma level-guided phenytoin use in arrhythmias; leaves open need for randomized confirmation.
Does diphenylhydantoin sodium suppress arrhythmias at specific plasma levels in patients with ventricular or atrial arrhythmias?
Diphenylhydantoin sodium effectively suppresses ventricular and digitalis-induced atrial arrhythmias at critical plasma levels of 10 to 18 µg/ml without depressing cardiac conduction.
Bigger et al. (1968) studied this question.
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