August 1, 1968CirculationOpen Access

Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic Effects

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Why the study?

Does diphenylhydantoin sodium suppress arrhythmias at specific plasma levels in patients with ventricular or atrial arrhythmias?

Structured PICO

Does diphenylhydantoin sodium suppress arrhythmias at specific plasma levels in patients with ventricular or atrial arrhythmias?

Population

Patients with a variety of arrhythmias, including ventricular arrhythmias in various clinical conditions and atrial tachycardia (particularly if caused by digitalis excess)

Intervention

Diphenylhydantoin sodium administered via multiple intravenous doses, single intravenous doses, or oral doses

Outcome

Abolition of arrhythmias in relation to plasma levels of diphenylhydantoin sodiumsurrogate

Diphenylhydantoin sodium effectively suppresses ventricular and digitalis-induced atrial arrhythmias at critical plasma levels of 10 to 18 µg/ml without depressing cardiac conduction.

Discussion

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Implication

May support plasma level-guided phenytoin use in arrhythmias; leaves open need for randomized confirmation.

Cite This Study

Bigger et al. (1968) studied this question.

synapsesocial.com/papers/6a205cdce6386eb04298f7c4 https://doi.org/10.1161/01.cir.38.2.363

Topics

Atrial fibrillation Persistent AF management

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Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic Effects

Structured PICO

Discussion

Implication

Cite This Study

Topics

Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic Effects

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider