Key result
Diphenylhydantoin sodium, procaine amide, procaine, and quinidine were approximately equally effective in reverting ouabain-induced ventricular tachycardia to normal sinus rhythm in dogs.
Why the study?
Do diphenylhydantoin sodium, procaine amide hydrochloride, procaine hydrochloride, and quinidine hydrochloride improve reversion to normal sinus rhythm in unanesthetized dogs with ouabain-induced ventricular tachycardia?
Population
Unanesthetized dogs with ouabain-induced ventricular tachycardia
Comparison
Diphenylhydantoin sodium, procaine amide… vs Compared against each other
Design
Preclinical
Authors
Loading...
Equal efficacy in canine ouabain VT warrants no practice change; leaves open translation to human digitalis toxicity.
Do diphenylhydantoin sodium, procaine amide hydrochloride, procaine hydrochloride, and quinidine hydrochloride improve reversion to normal sinus rhythm in unanesthetized dogs with ouabain-induced ventricular tachycardia?
Diphenylhydantoin sodium is effective in reversing ouabain-induced ventricular tachycardia in dogs, suggesting potential utility for digitalis-induced ventricular arrhythmias in humans.
Mosey et al. (1954) studied Ouabain-induced ventricular tachycardia. Diphenylhydantoin sodium, procaine amide hydrochloride, procaine hydrochloride, and quinidine hydrochloride vs. Each other was evaluated on Reversion to normal sinus rhythm. Diphenylhydantoin sodium, procaine amide, procaine, and quinidine were approximately equally effective in reverting ouabain-induced ventricular tachycardia to normal sinus rhythm in dogs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: