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October 21, 2019Journal of VirologyOpen Access

A Polyuridine Insertion in the 3′ Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets

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Why the study?

Classical swine fever remains endemic in some regions, and the 3' untranslated region plays an important role in flavivirus replication.

Population

Piglets

Authors

MWMiaomiao WangZhejiang Sci-Tech UniversityMLMatthias LinigerUniversity of BernSMSara Muñoz‐GonzálezCentre de Recerca en Sanitat Animal

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Implication

May attenuate CSFV in piglets via 3' UTR engineering; hypothesis-generating for live vaccines before field validation.

Structured PICO

P
Population
Piglets infected with Classical swine fever virus (CSFV)
I
Intervention
Endemic CSFV isolate with a long polyuridine sequence acquired in the 3' untranslated region (3' UTR)
O
Outcome
Activation of immunity, control of viral replication, and modulation of diseasesurrogate

A polyuridine insertion in the 3' UTR of CSFV reduces viral virulence and activates immunity, providing a potential target for novel vaccine development.

Cite This Study

Wang et al. (2019) studied this question.

synapsesocial.com/papers/6a8bc5e9c716e89f35def844https://doi.org/10.1128/jvi.01214-19
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA1996 · 207 citations
  2. 2Classical Swine Fever Virus vs. Classical Swine Fever Virus: The Superinfection Exclusion Phenomenon in Experimentally Infected Wild Boar2016 · 27 citations
  3. 3Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy2015 · 49 citations
  4. 4Essential and Nonessential Elements in the 3′ Nontranslated Region of Bovine Viral Diarrhea Virus2005 · 54 citations
  5. 5Classical Swine Fever Virus N<sup>pro</sup>Interacts with Interferon Regulatory Factor 3 and Induces Its Proteasomal Degradation2007 · 205 citations