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October 1, 1988Journal of Applied Physiology

Hindlimb suspension increases insulin binding and glucose metabolism

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Population

Young (18-day-old) and adult (150-day-old) rats

Comparison

28 days of hindlimb-suspension vs Age-matched controls

Design

Preclinical

Follow-up

28 days

Authors

ABArend BonenUniversity of GuelphGEGeoffrey C. B. ElderMcMaster UniversityMTM. H. TanDalhousie University

Discussion

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Overview

Indicates compensatory adaptation in rodent disuse; hypothesis-generating and should not yet influence clinical practice.

Structured PICO

P
Population
Young (18-day-old) and adult (150-day-old) rats
I
Intervention
28 days of hindlimb-suspension
C
Comparator
Age-matched controls
O
Outcome
Insulin binding, 2-deoxy-D-glucose (2-DG) uptake, and glucose metabolism (glycolysis and glycogenesis) in soleus muscle at various insulin concentrations (0.2-30 nM)surrogate

Hindlimb suspension leads to marked increases in insulin binding and glucose metabolism per milligram of protein in the soleus muscle of rats, likely as a compensatory response to atrophy.

Cite This Study

Bonen et al. (1988) studied this question.

synapsesocial.com/papers/6a8bc733f8241cb45bfb6a6ehttps://doi.org/10.1152/jappl.1988.65.4.1833
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