Intravenous amiodarone may induce acute hepatitis, but liver function can normalize even if the infusion is continued.
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IV amiodarone may trigger acute hepatitis that normalizes despite continued infusion; Level 5 evidence leaves open causality and management.
Two patients with acute changes suggesting acute hepatitis after parenteral amiodarone administration are described. No other explanation for liver damage was found in these patients. Normalization of liver function in spite of continuation of drug infusion was observed.
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Morelli et al. (2008) studied this question.
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