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September 28, 2016Basic Research in CardiologyOpen Access

Inhibition of cardiac CaMKII to cure heart failure: step by step towards translation?

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Population

transgenic mouse models of heart failure

Design

Editorial

Authors

FCFriederike CuelloKLKristina Lorenz

Discussion

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Overview

May inform CaMKII-targeted HF therapies; leaves open clinical translation from preclinical models.

Structured PICO

P
Population
transgenic mouse models of heart failure
I
Intervention
CaMKII inhibition / knockdown of cardiac CaMKII isoforms
O
Outcome
reversal of maladaptive cardiac remodeling processes

This editorial highlights the potential of CaMKII inhibition as a therapeutic strategy to reverse maladaptive cardiac remodeling in heart failure.

Cite This Study

Cuello et al. (2016) studied this question.

synapsesocial.com/papers/6a8bc872f07ad6ed43b22c99https://doi.org/10.1007/s00395-016-0582-1
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