Why the study?
Does ruboxistaurin improve cardiac function in a pig model of myocardial infarction-induced heart failure?
Population
20-kg pigs with myocardial infarction-induced heart failure (via left anterior descending artery occlusion)
Comparison
Ruboxistaurin administered via feed for 3 months vs Vehicle feed
Design
Preclinical
Follow-up
3 months
Authors
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No immediate change to post-MI HF management; leaves open translation of PKC inhibition to human trials.
Does ruboxistaurin improve cardiac function in a pig model of myocardial infarction-induced heart failure?
Inhibition of PKCα/β with ruboxistaurin improves cardiac function and antagonizes heart failure in a large animal (pig) model of post-MI heart failure.
Ladage et al. (2011) studied this question.
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