Population
Myosin subfragment 2 (S2), both short (residues 3-287) and long (residues 1-440) forms
Comparison
5,5'-dithiobis to produce interchain disulfide… vs Un-cross-linked species
Design
Preclinical
Authors
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Does not inform clinical myosin-targeted therapies; leaves open whether disulfide bonds modulate cardiac contractility in vivo.
This basic science study characterizes the biochemical and structural effects of interchain disulfide cross-links on myosin subfragment 2.
Lu et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: