Population
Myosin and its proteolytic fragments (light meromyosin, subfragment-1, subfragment-2)
Design
Preclinical
Authors
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Requires validation in intact cardiac muscle; leaves open whether pH modulates contractility in vivo.
pH changes can modulate the relative structural stabilities of different regions of the myosin molecule.
Goodno et al. (1976) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: