Key result
Increasing temperature markedly accelerates myosin cleavage, suggesting substantial thermal destabilization of the released cross-bridge.
Population
Rigor myofibrils and glycerinated psoas fibers
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open thermal effects on myosin cross-bridge kinetics in human myocardium.
The study demonstrates that conformational melting in the myosin subfragment-2 hinge region is amplified upon activation, providing insights into muscle contraction mechanisms.
Ueno et al. (1986) studied this question. Temperature variation (5 to 40 degrees C) was evaluated on Intrinsic cleavage rate constant (k) of myosin heavy chain. Increasing temperature from 5 to 40 degrees C markedly increased the intrinsic cleavage rate constant of myosin, suggesting substantial thermal destabilization of the released cross-bridge.
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