Why the study?
Does intravenous Org 6001 and disopyramide prevent early ischaemia-induced arrhythmias and electrical deaths in anaesthetized rats when given postligation?
Does intravenous Org 6001 and disopyramide prevent early ischaemia-induced arrhythmias and electrical deaths in anaesthetized rats when given postligation?
Postligation administration of Org 6001 and disopyramide protects against early ischaemia-induced arrhythmias and electrical deaths in a rat model, extending their known prophylactic benefits.
Post-ligation antiarrhythmic protection in rats does not alter clinical practice; leaves open translation to human post-MI arrhythmia prevention.
The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation-induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).
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Marshall et al. (1982) studied this question.
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