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October 1, 1971The Journal of Infectious Diseases

Deactivation of Cholera Toxin by Ganglioside

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Why the study?

Does purified ganglioside neutralize the effect of cholera toxin in intestinal loops of rabbits and epididymal fat cells of rats?

Population

Intestinal loops of rabbits and epididymal fat cells of rats

Design

Preclinical

Authors

WHW. E. van HeyningenUniversity of North Carolina at Chapel HillCCCharles C. J. CarpenterCardiff and Vale University Health BoardNPN. F. PierceJohns Hopkins University

Discussion

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Implication

No immediate clinical implications for cholera; leaves open ganglioside neutralization as a mechanistic research avenue.

Structured PICO

Does purified ganglioside neutralize the effect of cholera toxin in intestinal loops of rabbits and epididymal fat cells of rats?

P
Population
Intestinal loops of rabbits and epididymal fat cells of rats
I
Intervention
Purified ganglioside
O
Outcome
Neutralization of the effect of cholera toxinsurrogate

This preclinical study demonstrates that gangliosides can neutralize cholera toxin, suggesting a mechanism for toxin binding to cell membranes.

Cite This Study

Heyningen et al. (1971) studied this question.

synapsesocial.com/papers/6a8bceafb676b7d1a2fb7db4https://doi.org/10.1093/infdis/124.4.415
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations
  2. 2The Fixation of Tetanus Toxin by Ganglioside1961 · 184 citations
  3. 3Titration of Cholera Enterotoxin and Antitoxin in Isolated Fat Cells1970 · 55 citations
  4. 4The Titration of Cholera Toxin and Antitoxin in the Rabbit Ileal Loop1966 · 127 citations