Why the study?
Does cardiomyocyte-specific overexpression of PID1 exacerbate pressure overload-induced cardiac hypertrophy in mice?
Does cardiomyocyte-specific overexpression of PID1 exacerbate pressure overload-induced cardiac hypertrophy in mice?
PID1 overexpression promotes cardiac hypertrophy and dysfunction under pathological conditions via regulation of the Akt and MAPK pathways.
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Cardiomyocyte PID1 overexpression worsens pressure-overload cardiomyopathy in mice; hypothesis-generating for PID1 inhibition in human heart failure.
Liu et al. (2015) studied this question.
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