Why the study?
Does diazepam reduce the required dosage, cardiovascular stimulation, and psychotomimetic side effects of continuous intravenous ketamine in women undergoing non-abdominal surgery?
Population
64 women undergoing non-abdominal operations
Comparison
Ketamine combined with diazepam 10 mg i.v. at… vs Ketamine combined with placebo 10 mg i.v. at…
Design
RCT, Randomized, Double-blind
Authors
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May support diazepam co-administration to lower ketamine dosing and effects; extends evidence but leaves routine adult use open due to residual risks.
Does diazepam reduce the required dosage, cardiovascular stimulation, and psychotomimetic side effects of continuous intravenous ketamine in women undergoing non-abdominal surgery?
Adding diazepam to continuous ketamine infusion reduces required ketamine dose, cardiovascular stimulation, and psychotomimetic side effects, though side effects remain too high for routine adult use.
Tore Pedersen (1982) studied this question.
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