Why the study?
Does Coxsackievirus B4 induce proinflammatory cytokine production in human pancreatic cells through toll-like receptors?
Population
Human pancreatic cells
Design
Preclinical
Authors
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May inform TLR4-targeted strategies in virus-associated diabetes; leaves open translation from animal models to human disease.
Does Coxsackievirus B4 induce proinflammatory cytokine production in human pancreatic cells through toll-like receptors?
Coxsackievirus B4 induces proinflammatory cytokine production in human pancreatic cells via a TLR4-dependent pathway, providing mechanistic insight into virus-induced pancreatic cell damage in insulin-dependent diabetes mellitus.
Triantafilou et al. (2004) studied this question.
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