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May 1, 1975CirculationOpen Access

Corrected sinus node recovery time. Experimental physiologic and pathologic determinants.

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Why the study?

What factors affect the reproducibility of corrected sinus node recovery time in an experimental model?

Population

36 anesthetized dogs

Comparison

Various pacing rates, pacing durations… vs Baseline or different levels of the same…

Design

Preclinical

Authors

KCKul D. ChaddaMount Sinai HospitalVBV. S. BankaTD BankMBMonty BodenheimerWestern University

Discussion

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Overview

CSNRT assessment in experimental models requires control for pacing rate and autonomic tone; leaves open optimal protocols for clinical sinus node testing.

Structured PICO

What factors affect the reproducibility of corrected sinus node recovery time in an experimental model?

P
Population
36 anesthetized dogs
I
Intervention
Various pacing rates (140 to 200 beats/min), pacing durations (1-60 min), milliamperage, vagal and beta-adrenergic stimulation, and sinus node injury
C
Comparator
Baseline or different levels of the same interventions
O
Outcome
Corrected sinus node recovery time (CSNRT) and its reproducibilitysurrogate

Corrected sinus node recovery time is highly dependent on pacing rate, duration, autonomic tone, and sinus node injury, indicating that clinical assessments must account for these variables.

Cite This Study

Chadda et al. (1975) studied this question.

synapsesocial.com/papers/6a8bd6a8c12eaf65c8b21ecbhttps://doi.org/10.1161/01.cir.51.5.797
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Significance of the Sinus-Node Recovery Time1972 · 461 citations
  2. 2Atrial pacing for sick sinus syndrome1990 · 38 citations
  3. 3Evaluation of Sino-atrial Node Function in Man by Overdrive Suppression1971 · 409 citations
  4. 4Sinoatrial-Node Entrance Block1971 · 101 citations
  5. 5Premature Atrial Stimulation as a Key to the Understanding of Sinoatrial Conduction in Man1973 · 453 citations