March 1, 1997Clinical Chemistry

Immunoassay of insulin-like growth factor binding protein-1

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Population

Biological fluid samples including serum, synovial fluid, cerebrospinal fluid, and amniotic fluid

Comparison

ELISA-1 vs ELISA-2, ELISA-3, and a commercial IGFBP-1 IRMA

Design

Other

Authors

MKM. Javad KhosraviIslamic Azad University of Shahrekord ADAnastasia DiamandiU.S. Army Research Institute of Environmental Medicine JMJehangir MistryNovartis (United Kingdom)

Discussion

Member takes

Implication

ELISA-1 enables accurate IGFBP-1 quantification independent of phosphorylation; leaves open its impact on clinical interpretation or research conclusions.

Structured PICO

Population

Biological fluid samples including serum, synovial fluid (SF), cerebrospinal fluid (CSF), and amniotic fluid (AF)

Intervention

ELISA-1 (using a specific detection antibody unaffected by phosphorylation)

Comparator

ELISA-2, ELISA-3, and a commercial IGFBP-1 IRMA

Outcome

IGFBP-1 concentration measurement accuracy before and after alkaline phosphatase (ALP) treatmentsurrogate

A newly developed ELISA (ELISA-1) accurately measures IGFBP-1 independent of its phosphorylation status, overcoming underestimation issues in existing assays.

Cite This Study

Khosravi et al. (1997) studied this question.

synapsesocial.com/papers/6a8bd6b7f8241cb45bfb6f1e https://doi.org/10.1093/clinchem/43.3.523

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Implication

ELISA-1 enables accurate IGFBP-1 quantification independent of phosphorylation; leaves open its impact on clinical interpretation or research conclusions.

Immunoassay of insulin-like growth factor binding protein-1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Immunoassay of insulin-like growth factor binding protein-1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider