What question did this study set out to answer?

To determine whether pulmonary arterial wave reflection can be assessed non-invasively in dogs with suspected pulmonary hypertension using Doppler echocardiography and wave intensity analysis, and to validate the technique against cardiac catheterization.

July 9, 2021Frontiers in Veterinary ScienceOpen Access

Non-invasive Assessment of Pulmonary Artery Wave Reflection in Dogs With Suspected Pulmonary Hypertension

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Why the study?

Cardiac catheterization to assess pulmonary arterial wave reflection is invasive and requires anesthesia, limiting its use in small animal medicine.

Can pulmonary arterial wave reflection be assessed non-invasively using Doppler echocardiography in dogs with suspected pulmonary hypertension?

Comparison

Suspected PH vs without echocardiographic evidence of PH, and Doppler echocardiography vs cardiac catheterization

Design

Clinical cohort and experimental validation study

Authors

TYTomohiko YoshidaObihiro University of Agriculture and Veterinary Medicine KMKatsuhiro MatsuuraUniversity of Florida SGSeijirow GoyaNihon University

Discussion

Member takes

Implication

Noninvasive wave reflection assessment is feasible in canine PH; hypothesis-generating for prognosis and requires prospective validation.

Key Points

To determine whether pulmonary arterial wave reflection can be assessed non-invasively in dogs with suspected pulmonary hypertension using Doppler echocardiography and wave intensity analysis, and to validate the technique against cardiac catheterization.
Evaluated 51 client-owned dogs presenting with tricuspid valve regurgitation (35 dogs with suspected pulmonary hypertension and 16 dogs without echocardiographic evidence of PH) for clinical outcomes and survival.
Calculated the reflection coefficient (ratio of peak backward to peak forward pressure) using wave intensity analysis derived from tricuspid regurgitation Doppler flow velocity profiles.
Validated the echocardiographic reflection coefficient against invasive cardiac catheterization in 8 healthy beagle dogs with experimentally induced acute pulmonary embolism.
The reflection coefficient was significantly higher in dogs with suspected pulmonary hypertension than in control dogs without PH (0.59 ± 0.21 vs. 0.18 ± 0.13, P < 0.001).
Dogs with a reflection coefficient > 0.48 experienced significantly shorter survival times than those with an RC < 0.48 (median survival 110 days vs. 353 days; log-rank χ² = 9.8, P = 0.0018).
Non-invasive reflection coefficients strongly correlated with values obtained via invasive cardiac catheterization during validation testing (r = 0.81, P < 0.001).

Structured PICO

Can pulmonary arterial wave reflection be assessed non-invasively using Doppler echocardiography in dogs with suspected pulmonary hypertension?

Population

51 client-owned dogs with tricuspid valve regurgitation (35 with suspected pulmonary hypertension, 16 without echocardiographic evidence of PH) and 8 healthy beagle dogs for validation.

Intervention

Non-invasive assessment of pulmonary arterial wave reflection (PAWR) using Doppler echocardiography based on wave intensity analysis (WIA).

Comparator

Dogs without echocardiographic evidence of pulmonary hypertension (clinical study) and cardiac catheterization (validation study).

Outcome

Reflection coefficient (RC) and its correlation with survival time and cardiac catheterization measurements.surrogate

Non-invasive assessment of pulmonary arterial wave reflection using echocardiography is feasible in dogs and correlates with prognosis in pulmonary hypertension.

Cite This Study

Yoshida et al. (2021) studied this question.

synapsesocial.com/papers/6a8bd6fe634d203318b20ca8 https://doi.org/10.3389/fvets.2021.659194

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Non-invasive Assessment of Pulmonary Artery Wave Reflection in Dogs With Suspected Pulmonary Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Non-invasive Assessment of Pulmonary Artery Wave Reflection in Dogs With Suspected Pulmonary Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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