What question did this study set out to answer?

This research aims to determine if mid-systolic deceleration of the pulmonary flow wave is associated with reflection during acute pulmonary hypertension.

February 1, 1991Cardiovascular Research

Reflection as a cause of mid-systolic deceleration of pulmonary flow wave in dogs with acute pulmonary hypertension: comparison of pulmonary artery constriction with pulmonary embolisation

Q: What is the clinical evidence from this study?

Study design: Other. Population: Acute pulmonary hypertension (n=10). Intervention: Pulmonary artery constriction vs. Pulmonary embolisation. Primary outcome: Mid-systolic deceleration of the pulmonary flow wave.

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Key result

Pulmonary artery constriction caused mid-systolic deceleration of the pulmonary flow wave in 5 of 10 dogs, whereas pulmonary embolisation did not, indicating a relationship to wave reflection.

Why the study?

Does pulmonary artery constriction or pulmonary embolisation cause mid-systolic deceleration of the pulmonary flow wave related to reflection in dogs with acute pulmonary hypertension?

Population

10 adult mongrel dogs (out of 20 initially used, 10 died and were excluded)

Comparison

Induction of acute pulmonary hypertension via… vs Control periods (baseline before interventions)

Design

Preclinical

Authors

YFY. FurunoUniversity of Occupational and Environmental Health Japan YNY. NagamotoKurume University MFMasatoshi FujitaUniversity of Fukui

Discussion

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Implication

Wave reflection may explain deceleration in constriction but not embolisation; leaves open applicability to clinical pulmonary hypertension.

Key Points

This research aims to determine if mid-systolic deceleration of the pulmonary flow wave is associated with reflection during acute pulmonary hypertension.
Induced various degrees of pulmonary hypertension using pulmonary artery constriction and pulmonary embolisation in dogs.
Measured pulmonary flow and artery pressure during control and induced hypertension periods.
Applied Westerhof's method to separate forward and backward flow waves from the total pulmonary flow wave.
Mid-systolic deceleration of the pulmonary flow wave was seen in 5 out of 10 dogs during pulmonary artery constriction.
No mid-systolic deceleration was detected during pulmonary embolisation in those same dogs.
The deceleration correlated with a significant drop and early negative peak in the backward flow wave.

Structured PICO

Does pulmonary artery constriction or pulmonary embolisation cause mid-systolic deceleration of the pulmonary flow wave related to reflection in dogs with acute pulmonary hypertension?

Population

10 adult mongrel dogs subjected to pulmonary artery constriction and pulmonary embolisation to induce acute pulmonary hypertension.

Intervention

Induction of acute pulmonary hypertension via pulmonary artery constriction and pulmonary embolisation

Comparator

Control periods (baseline before interventions)

Outcome

Presence of mid-systolic deceleration of the pulmonary flow wave and its relation to reflection (forward and backward flow waves)surrogate

Main Result

Absolute Event Rate: 50% vs 0%

Mid-systolic deceleration of the pulmonary flow wave in acute pulmonary hypertension is likely related to wave reflection, occurring during pulmonary artery constriction but not embolisation.

Limitations

High mortality rate during the experiment (10 out of 20 dogs died before both interventions were completed and were excluded)

Cite This Study

Furuno et al. (1991) studied Acute pulmonary hypertension (n=10). Pulmonary artery constriction vs. Pulmonary embolisation was evaluated on Mid-systolic deceleration of the pulmonary flow wave. Pulmonary artery constriction caused mid-systolic deceleration of the pulmonary flow wave in 5 of 10 dogs, whereas pulmonary embolisation did not, indicating a relationship to wave reflection.

synapsesocial.com/papers/6a1feed7f35583189204b461 https://doi.org/10.1093/cvr/25.2.118

Topics

Pulmonary embolism

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Implication

Wave reflection may explain deceleration in constriction but not embolisation; leaves open applicability to clinical pulmonary hypertension.

Reflection as a cause of mid-systolic deceleration of pulmonary flow wave in dogs with acute pulmonary hypertension: comparison of pulmonary artery constriction with pulmonary embolisation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Reflection as a cause of mid-systolic deceleration of pulmonary flow wave in dogs with acute pulmonary hypertension: comparison of pulmonary artery constriction with pulmonary embolisation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

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