Why the study?
Does oral tocainide reduce VPB activity compared to disopyramide in outpatients with stable ventricular premature beats?
Population
10 outpatients with stable ventricular premature beats (VPBs)
Comparison
Oral tocainide vs Oral disopyramide
Design
RCT, double-blind
Follow-up
18-h
Authors
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Either drug may aid VPB suppression in stable outpatients; confirms Holter efficacy while leaving exercise response and safety open.
Does oral tocainide reduce VPB activity compared to disopyramide in outpatients with stable ventricular premature beats?
Both oral tocainide and disopyramide effectively reduce ventricular premature beat frequency and grade during Holter monitoring, though their effects during exercise vary.
McLaran et al. (1984) studied this question.
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