This basic science study demonstrates that the sarcolemmal Ca2+-ATPase has a different subcellular distribution compared to the DHP receptor and Na+/Ca2+ exchanger in ventricular myocytes.
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Differential Ca2+-ATPase localization warrants no clinical change; leaves open its role in human myocyte Ca2+ handling.
We have investigated the distribution of the sarcolemmal Ca2+ transporters in hamster and dog ventricular myocytes by immunocytochemical and membrane fractionation techniques. The data suggest that the DHP receptor alpha 1 subunit and the Na+/Ca2+ exchanger are present in surface sarcolemma as well as T-tubule membranes located at the cardiac dyads. Compared with these Ca2+ transporters, the sarcolemmal Ca(2+)-ATPase is much less abundant in the latter fraction. Thus the sarcolemmal Ca(2+)-ATPase seems to be located predominantly in surface sarcolemma.
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Iwata et al. (1994) studied this question.
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