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November 21, 1994FEBS Letters

Ca2+‐ATPase distributes differently in cardiac sarcolemma than dihydropyridine receptor α1 subunit and Na+/Ca2+ exchanger

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Population

Hamster and dog ventricular myocytes

Design

Preclinical

Authors

YIYuko IwataHHHironori HanadaMTMasami Takahashi

Discussion

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Overview

Differential Ca2+-ATPase localization warrants no clinical change; leaves open its role in human myocyte Ca2+ handling.

Structured PICO

P
Population
Hamster and dog ventricular myocytes
I
Intervention
Immunocytochemical and membrane fractionation techniques
O
Outcome
Distribution of sarcolemmal Ca2+ transporters (DHP receptor alpha 1 subunit, Na+/Ca2+ exchanger, and sarcolemmal Ca2+-ATPase)surrogate

This basic science study demonstrates that the sarcolemmal Ca2+-ATPase has a different subcellular distribution compared to the DHP receptor and Na+/Ca2+ exchanger in ventricular myocytes.

Cite This Study

Iwata et al. (1994) studied this question.

synapsesocial.com/papers/6a8bdcab52e1a91077e9811ahttps://doi.org/10.1016/0014-5793(94)01174-5
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