Why the study?
Increased blood pressure variability and inflammation predict cardiovascular events in type 2 diabetes and hypertension, but whether C-reactive protein is associated with increased blood pressure variability was unknown.
Is high C-reactive protein associated with increased blood pressure variability in diabetic-hypertensive patients?
Is high C-reactive protein associated with increased blood pressure variability in diabetic-hypertensive patients?
In diabetic-hypertensive patients, higher CRP levels are associated with cardiometabolic derangements but not with increased blood pressure variability.
Answers are grounded in this paper and cite their sources.
No CRP-BP variability link in diabetic hypertension; hypothesis-generating and requires longitudinal confirmation before clinical consideration.
OBJECTIVE: Increased blood pressure (BP) variability and inflammation are included among the factors recognized as potential predictors of cardiovascular events in type 2 diabetes and hypertension. This study aimed to evaluate whether C-reactive protein (CRP) is associated with increased BP variability in diabetic-hypertensive patients. PATIENTS AND METHODS: We carried out a cross-sectional study with 285 diabetic-hypertensive patients, evaluating laboratory characteristics and 24-h ambulatory BP monitoring. SD, coefficient of variation (CV%), time-rate index of 24-h systolic BP (SBP), and 24-h BP patterns were evaluated. Pearson's χ-test, Student's t-test, and the Mann-Whitney test were used to compare the groups. Groups were defined by CRP of up to 3 mg/l (low) and more than 3 mg/l (high). RESULTS: The age of the patients was 59 (54-62) years; 101 (35%) were men. There was an increase in office SBP [137 (127-148) vs. 145 (130-157) mmHg] and DBP [79 (73-86) vs. 82 (76-91) mmHg] in the high CRP group. Blood pressure variability indexes were not different among groups [SD: 11.2 (9-15) vs. 12.2 (10-15) mmHg; CV%: 8.6 (7-11) vs. 9.4 (7-12); time rate: 0.55±0.12 vs.12.2 (10-15) mmHg/min]. In addition, BMI (29.3±3.8 vs. 30.9±3.6 kg/m), total cholesterol [166 (148-190) vs. 177 (156-210) mg/dl], and HbA1c [7.5% (6.6-8.9) vs.8.3% (7.1-9.9)] were higher in the high CRP group. CONCLUSION: In patients with diabetes and hypertension, higher CRP levels are linked to cardiometabolic derangements, although they are not associated with increased BP variability.
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Schein et al. (2019) studied this question.
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