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May 1, 1975Journal of VirologyOpen Access

Antibody-induced capping of measles virus antigens on plasma membrane studied by electron microscopy

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Population

HeLa cells infected with measles virus

Comparison

Antibodies specific for measles virus at 37 C vs Antibodies specific for measles virus at 4 C

Design

Preclinical

Authors

PLPeter W. LampertKarlstad University

Discussion

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Overview

Antibody-mediated measles antigen clustering may enable membrane stripping; leaves open in vivo relevance or therapeutic implications.

Structured PICO

P
Population
HeLa cells infected with measles virus
I
Intervention
Antibodies specific for measles virus at 37 C
C
Comparator
Antibodies specific for measles virus at 4 C
O
Outcome
Redistribution ("capping") of virus antigens on the plasma membranesurrogate

Antiviral antibodies can move and cluster measles virus antigens on plasma membranes, suggesting virus-antibody complexes are stripped and shed from the cell surface.

Cite This Study

Peter W. Lampert (1975) studied this question.

synapsesocial.com/papers/6a8be2b2b676b7d1a2fb8468https://doi.org/10.1128/jvi.15.5.1248-1255.1975
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