Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus

French Caucasian families including 179 hypertensive sibpairs from 69 non-insulin-dependent diabetes mellitus (NIDDM) kindreds, and unrelated individuals with both hypertension and NIDDM (n=188), NIDDM alone (n=117), hypertension alone (n=75), or neither condition (n=125).

Assessment of M235T and T174M polymorphisms of the angiotensinogen (AGT) gene, and the A1166C polymorphism of the angiotensin II type 1 (AT1) receptor gene.

Control subjects with NIDDM alone, hypertension alone, or neither condition.

Linkage between the AGT and AT1 receptor loci and hypertension, and distribution of genotypes among groups.surrogate