Population
Five hypertensive rat strains and their normotensive controls, as well as Xenopus laevis oocytes for…
Comparison
Genetic sequencing of the C-terminal regions of… vs Normotensive control rat strains.
Design
Preclinical
Authors
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Does not support ENaC C-terminus mutations in rat hypertension models; leaves open their role in human essential hypertension.
Mutations in the C-terminus of the epithelial sodium channel do not appear to contribute to the hypertensive phenotype in five common rat models of essential hypertension.
Gründer et al. (1997) studied this question.
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