Distinctive Left-Sided Distribution of Adrenergic-Derived Cells in the Adult Mouse Heart

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Population

Adult mice (genetic fate-mapping model: Pnmt-Cre mice cross-mated with homozygous Rosa26 reporter (R26R) mice)

Design

Preclinical

Authors

Discussion

Hypothesis-generating in mice; leaves open human relevance and any clinical implications.

Population

Adult mice (genetic fate-mapping model: Pnmt-Cre mice cross-mated with homozygous Rosa26 reporter (R26R) mice)

Intervention

Genetic fate-mapping to express β-galactosidase (βGAL) reporter gene in cells of an adrenergic lineage

Outcome

Anatomical localization and distribution of cells derived from an adrenergic lineage within the adult heartsurrogate

Adrenergic-derived cells display a distinctive, predominantly left-sided distribution pattern in the adult mouse heart.

Osuala et al. (2011) studied this question.

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