Why the study?
Does low molecular weight heparin reduce deep-vein thrombosis compared to unfractionated heparin and warfarin in patients undergoing orthopaedic surgery?
Population
Patients undergoing orthopaedic surgery (meta-analysis of 22 randomised clinical trials)
Comparison
Low molecular weight heparin (LMWH) vs Unfractionated heparin (UFH) and warfarin
Design
Meta-analysis
Authors
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LMWH preferred for DVT prophylaxis in orthopaedic surgery; confirms Level 1 superiority versus UFH and warfarin.
Does low molecular weight heparin reduce deep-vein thrombosis compared to unfractionated heparin and warfarin in patients undergoing orthopaedic surgery?
In orthopaedic surgery, LMWH is superior to both UFH and warfarin for DVT prevention, with a minor bleeding risk that is lower than UFH but higher than warfarin.
Palmer et al. (2009) studied this question.
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