Key result
Low-molecular-weight heparin was superior to aspirin in preventing venous thromboembolism after orthopaedic surgery (OR 1.44; 95% CI 1.24-1.68; P<0.00001), with no significant difference in bleeding.
Why the study?
The efficiency and safety of aspirin compared with low-molecular-weight heparin for thromboprophylaxis in orthopaedic surgery patients needed evaluation.
Does aspirin prevent VTE events as effectively as low-molecular-weight heparin in orthopaedic surgery patients?
Population
12 470 patients in the aspirin group and 10 857 patients in the LMWH group across six studies
Comparison
Aspirin vs low-molecular-weight heparin (LMWH)
Design
Systematic review and meta-analysis
Authors
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LMWH should be prioritized over aspirin for VTE prophylaxis in orthopaedic surgery; reinforces Level 1 evidence of superiority without bleeding trade-off.
Meta-Analysis (n=23,327)
Does aspirin prevent VTE events as effectively as low-molecular-weight heparin in orthopaedic surgery patients?
Odds Ratio: 1.44 (95% CI 1.24–1.68)
p-value: p=< 0.00001
LMWH is significantly superior to aspirin for thromboprophylaxis after orthopaedic surgery, with a similar safety profile regarding bleeding and wound complications.
Wu et al. (2024) conducted a meta-analysis in Orthopaedic surgery (n=23,327). Aspirin vs. Low-molecular-weight heparin (LMWH) was evaluated on Venous thromboembolism (VTE) events (OR 1.44, 95% CI 1.24-1.68, p=< 0.00001). Low-molecular-weight heparin was superior to aspirin in preventing venous thromboembolism after orthopaedic surgery (OR 1.44; 95% CI 1.24-1.68; P<0.00001), with no significant difference in bleeding.
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