Population
Source, finished, and tap water samples from three drinking water treatment plant systems
Comparison
Multiplex integrated cell culture-PCR using… vs Total culturable virus assay (TCVA)
Design
Other
Authors
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ICC-PCR may underestimate total infectious virus in water due to primer gaps; leaves open broader assay validation for environmental monitoring.
While multiplex ICC-PCR offers high sensitivity for targeted viruses, its overall detection reliability for total infectious viruses in water samples is limited by the specific primers used, potentially underestimating viral loads compared to traditional cell culture assays.
Lee et al. (2004) studied this question.
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