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November 1, 2001British Journal of PharmacologyOpen Access

Vasoconstrictor activity of novel endothelin peptide, ET‐1(1 – 31), in human mammary and coronary arteries in vitro

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Population

Isolated endothelium-denuded preparations of human coronary and internal mammary arteries

Comparison

ET-1(1-31) vs ET-1 and big ET-1

Design

Preclinical

Authors

JMJanet J. MaguireUniversity of Cambridge RKRhoda E. KucSkolkovo Institute of Science and Technology ADAnthony P. DavenportVascular Medicine

Discussion

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Implication

ET-1(1-31) may act as alternative ET-1 precursor in human vessels; hypothesis-generating for its role in cardiovascular disease.

Structured PICO

P

Population

Isolated endothelium-denuded preparations of human coronary and internal mammary arteries

I

Intervention

ET-1(1-31)

C

Comparator

ET-1 and big ET-1

O

Outcome

Vasoconstrictor response (pD2 values)surrogate

ET-1(1-31) mediates vasoconstriction in human arteries via ET(A) receptor activation, suggesting it may represent an alternative precursor for ET-1 production in the human vasculature.

Cite This Study

Maguire et al. (2001) studied this question.

synapsesocial.com/papers/6a8be8fa0c58d86fb4cae5e2 https://doi.org/10.1038/sj.bjp.0704384

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects of Phosphoramidon and Pepstatin a on the Secretion of Endothelin-I and Big Endothelin-I by Human Umbilical Vein Endothelial Cells: Measurement by Two-Site Enzyme-Linked Immunosorbent Assays1994 · 26 citations
2The effect of the ETA receptor antagonist, FR 139317, on [125I]‐ET‐1 binding to the atherosclerotic human coronary artery1994 · 33 citations
3Expression of Endothelin Peptides and Mrna in the Human Heart1996 · 63 citations
4Increased response to big endothelin‐1 in atherosclerotic human coronary artery: functional evidence for up‐regulation of endothelin‐converting enzyme activity in disease1998 · 40 citations
5Secretory pathways in endothelin synthesis1999 · 124 citations