June 1, 1982Clinical Science
The Autonomic Nervous Tone Abnormalities in the Genesis of the Impaired Baroreflex Responsiveness in Borderline Hypertensive Subjects
Why the study?
Does intravenous administration of neostigmine and propranolol improve baroreflex responsiveness in borderline hypertensive subjects?
Population
18 borderline hypertensive subjects and 14 age-matched normal control subjects (total n=32).
Comparison
Intravenous administration of neostigmine and… vs Age-matched normal control subjects and baseline…
Design
Case-control
Authors
Discussion
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Implication
May indicate reversible autonomic impairment in borderline hypertension; leaves open whether neostigmine-propranolol alters outcomes.
Structured PICO
Does intravenous administration of neostigmine and propranolol improve baroreflex responsiveness in borderline hypertensive subjects?
P
Population
18 borderline hypertensive subjects and 14 age-matched normal control subjects (total n=32).
I
Intervention
Intravenous administration of neostigmine and propranolol, individually or in combination.
C
Comparator
Age-matched normal control subjects and baseline state.
O
Outcome
Baroreflex responsiveness (evaluated by heart rate response to phenylephrine-induced increase in arterial pressure, and heart rate and blood pressure changes induced by increasing neck-tissue pressure).surrogate
Impaired baroreflex responsiveness in borderline hypertension is primarily driven by reversible autonomic regulation abnormalities.
Cite This Study
Volpe et al. (1982) studied this question.